Article

Lower degree of microsatellite instability in colorectal carcinomas from <i>MSH6</i> -associated Lynch syndrome patients

2024-08-12

Abstract excerpt

<h4>Background</h4> Numerous observational and molecular studies focusing on Lynch syndrome (LS) have revealed significant variation in the phenotype and molecular characteristics among carriers of pathogenic variants in mismatch repair genes ( path_MMR ). Recently, we demonstrated that colorectal carcinomas in path_MSH6 carriers exhibit fewer insertion/deletion mutations compared to CRCs from other MMR groups,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a2122d28-c2f0-5e2e-8182-8ac64d41de4a
DOI: 10.1101/2024.08.12.607570

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lower degree of microsatellite instability in colorectal carcinomas from <i>MSH6</i> -associated Lynch syndrome patientsDOI 10.1101/2024.08.12.607570Read

Lower Degree of Microsatellite Instability in Colorectal Carcinomas From MSH6-Associated Lynch Syndrome PatientsSemantic proximity Read

Mutational signature profiling classifies subtypes of clinically different mismatch repair deficient tumors with a differential immunogenic response potentialSemantic proximity Read

The coding microsatellite mutation profile of PMS2-deficient colorectal cancerSemantic proximity Read

Immunological profiles in Lynch syndrome colorectal cancers are not specific to mismatch repair gene defectsSemantic proximity Read

Lynch Syndrome and MSI-H Cancers: From Mechanisms to “Off-The-Shelf” Cancer VaccinesSemantic proximity Read

Microsatellite instability in mismatch repair proficient colorectal cancer: clinical features and underlying molecular mechanisms.Semantic proximity Read

Prevalence estimation of microsatellite instability in colorectal cancers using tissue microarray based methods – A tertiary care center experienceSemantic proximity Read

Molecular analysis of Iranian colorectal cancer patients at risk for Lynch syndrome: a new molecular, clinicopathological feature.Semantic proximity Read

Prediction of biological behavior and prognosis of colorectal cancer patients by tumor MSI/MMR in the Chinese populationSemantic proximity Read

Mutational signature profiling classifies subtypes of clinically different mismatch-repair-deficient tumours with a differential immunogenic response potential.Semantic proximity Read

Cancer risks for<i>MSH6</i>pathogenic variant carriersSemantic proximity Read

Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1.Semantic proximity Read