Article

Measles-based Zika vaccine induces long-term immunity and requires NS1 antibodies to protect the female reproductive tract.

2020-09-28

Abstract excerpt

<title>Abstract</title> <p>Zika virus (ZIKV) can cause devastating effects in the unborn fetus of pregnant women. To develop a candidate vaccine that can protect human fetuses, we generated a panel of live measles vaccine (MV) vectors expressing ZIKV-E and -NS1. Our MV-based ZIKV-E vaccine, MV-E2, protected mice from the non-lethal Zika Asian strain (PRVABC59) and the lethal African strain (MR766) challenge. Desp...

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Literature Corpus work: a1e3b975-0e62-5059-bf9c-5d1b37130e26
DOI: 10.21203/rs.3.rs-71695/v1

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