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Article

Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

8 Feb 2018

Abstract excerpt

The global spread of Zika virus (ZIKV) and its unexpected association with congenital defects necessitates the rapid development of a safe and effective vaccine. Here we report the development and characterization of a recombinant chimeric ZIKV vaccine candidate (termed ChinZIKV) that expresses the prM-E proteins of ZIKV using the licensed Japanese encephalitis live-attenuated vaccine SA14-14-2 as the genetic...

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Malaria Research and Control
Mosquito-borne diseases and control
Viral Infections and Vectors

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29445153
DOI: 10.1038/s41467-018-02975-w

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