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Article

Cross-reactive Dengue virus-specific CD8+ T cells protect against Zika virus during pregnancy.

Nature communications - 2 Aug 2018

Regla-Nava Jose Angel, Elong Ngono Annie, Viramontes Karla M, Huynh Anh-Thy, Wang Ying-Ting, Nguyen Anh-Viet T, Salgado Rebecca, Mamidi Anila, Kim Kenneth, Diamond Michael S, Shresta Sujan

Abstract excerpt

As Zika virus (ZIKV) emerges into Dengue virus (DENV)-endemic areas, cases of ZIKV infection in DENV-immune pregnant women may rise. Here we show that prior DENV immunity affects maternal and fetal ZIKV infection in pregnancy using sequential DENV and ZIKV infection models. Fetuses in ZIKV-infected DENV-immune dams were normal sized, whereas fetal demise occurred in non-immune dams. Moreover, reduced ZIKV RNA is...

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Source

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Identifiers

PMID: 30072692
DOI: 10.1038/s41467-018-05458-0
PMCID: PMC6072705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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