Article
Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease.
Cell - 13 Jul 2017
Richner Justin M, Jagger Brett W, Shan Chao, Fontes Camila R, Dowd Kimberly A, Cao Bin, Himansu Sunny, Caine Elizabeth A, Nunes Bruno T D, Medeiros Daniele B A, Muruato Antonio E, Foreman Bryant M, Luo Huanle, Wang Tian, Barrett Alan D, Weaver Scott C, Vasconcelos Pedro F C, Rossi Shannan L, Ciaramella Giuseppe, Mysorekar Indira U, Pierson Theodore C, Shi Pei-Yong, Diamond Michael S
Abstract excerpt
The emergence of Zika virus (ZIKV) and its association with congenital malformations has prompted the rapid development of vaccines. Although efficacy with multiple viral vaccine platforms has been established in animals, no study has addressed protection during pregnancy. We tested in mice two vaccine platforms, a lipid nanoparticle-encapsulated modified mRNA vaccine encoding ZIKV prM and E genes and a...
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