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Article

A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage

18 Sept 2017

Abstract excerpt

Zika virus infection during pregnancy can cause congenital abnormities or fetal demise. The persistence of Zika virus in the male reproductive system poses a risk of sexual transmission. Here we demonstrate that live-attenuated Zika virus vaccine candidates containing deletions in the 3' untranslated region of the Zika virus genome (ZIKV-3'UTR-LAV) prevent viral transmission during pregnancy and testis damage in...

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PMID: 28939807
DOI: 10.1038/s41467-017-00737-8

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