Article
A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models.
Nature medicine - 1 Jun 2017
Shan Chao, Muruato Antonio E, Nunes Bruno T D, Luo Huanle, Xie Xuping, Medeiros Daniele B A, Wakamiya Maki, Tesh Robert B, Barrett Alan D, Wang Tian, Weaver Scott C, Vasconcelos Pedro F C, Rossi Shannan L, Shi Pei-Yong
Abstract excerpt
Zika virus (ZIKV) infection of pregnant women can cause a wide range of congenital abnormalities, including microcephaly, in the infant, a condition now collectively known as congenital ZIKV syndrome. A vaccine to prevent or significantly attenuate viremia in pregnant women who are residents of or travelers to epidemic or endemic regions is needed to avert congenital ZIKV syndrome, and might also help to suppress...
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