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Article

Essential Role of the EF-hand Domain in Targeting Sperm Phospholipase Cζ to Membrane Phosphatidylinositol 4,5-Bisphosphate (PIP2).

The Journal of biological chemistry - 4 Dec 2015

Nomikos Michail, Sanders Jessica R, Parthimos Dimitris, Buntwal Luke, Calver Brian L, Stamatiadis Panagiotis, Smith Adrian, Clue Matthew, Sideratou Zili, Swann Karl, Lai F Anthony

Abstract excerpt

Sperm-specific phospholipase C-ζ (PLCζ) is widely considered to be the physiological stimulus that triggers intracellular Ca(2+) oscillations and egg activation during mammalian fertilization. Although PLCζ is structurally similar to PLCδ1, it lacks a pleckstrin homology domain, and it remains unclear how PLCζ targets its phosphatidylinositol 4,5-bisphosphate (PIP2) membrane substrate. Recently, the PLCδ1 EF-hand...

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Identifiers

PMID: 26429913
DOI: 10.1074/jbc.M115.658443
PMCID: PMC4705952

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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