Article

A scalable proteogenomic framework for dissecting phospho-signaling pathways in primary immune cells

2025-10-08

Abstract excerpt

Signaling networks modulated by post-translational modifications orchestrate cellular responses to external cues. Traditional approaches to study these pathways lack the throughput to systematically capture the causal architecture of these signaling pathways at scale. Here, we present an integrated proteogenomic framework that combines saturating genetic perturbations with high-throughput proteomics to systematica...

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Literature Corpus work: a1ab5345-f488-50a3-b3db-675d02e454ea
DOI: 10.1101/2025.10.08.681012

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