Article

Nucleolar TFIIE plays a role in ribosomal biogenesis and performance

2020-12-16

Abstract excerpt

Ribosome biogenesis is a highly energy-demanding process in eukaryotes which requires the concerted action of all three RNA polymerases. In RNA polymerase II transcription, the general transcription factor TFIIH is recruited by TFIIE to the initiation site of protein-coding genes. Distinct mutations in TFIIH and TFIIE give rise to the degenerative disorder trichothiodystrophy (TTD). Here we uncovered an unexpected...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dacb03e2-8cf5-5209-a1fb-77b58a05f973
DOI: 10.1101/2020.12.16.423046

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nucleolar TFIIE plays a role in ribosomal biogenesis and performanceDOI 10.1101/2020.12.16.423046Read

Nucleolar TFIIE plays a role in ribosomal biogenesis and performance.Semantic proximity Read

Mutations in TFIIH causing trichothiodystrophy are responsible for defects in ribosomal RNA production and processing.Semantic proximity Read

Ribosomal Dysfunction Is a Common Pathomechanism in Different Forms of Trichothiodystrophy.Semantic proximity Read

TFIIH mutations can impact on translational fidelity of the ribosome.Semantic proximity Read

The essential and multifunctional TFIIH complexSemantic proximity Read

Treacle Sticks the Nucleolar Responses to DNA Damage TogetherSemantic proximity Read

Trichothiodystrophy causative TFIIEβ mutation affects transcription in highly differentiated tissue.Semantic proximity Read

A ubiquitous disordered protein interaction module orchestrates transcription elongation.Semantic proximity Read

Homozygous TAF8 mutation in a patient with intellectual disability results in undetectable TAF8 protein, but preserved RNA polymerase II transcription.Semantic proximity Read

The cryo-electron microscopy structure of human transcription factor IIH.Semantic proximity Read

The Role of TCOF1 Gene in Health and Disease: Beyond Treacher Collins SyndromeSemantic proximity Read

The mRNAs associated to a zinc finger protein fromTrypanosoma cruzishift during stress conditionsSemantic proximity Read