Article
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth.
The EMBO journal - 5 Oct 2005
Bi Meixia, Naczki Christine, Koritzinsky Marianne, Fels Diane, Blais Jaime, Hu Nianping, Harding Heather, Novoa Isabelle, Varia Mahesh, Raleigh James, Scheuner Donalyn, Kaufman Randal J, Bell John, Ron David, Wouters Bradly G, Koumenis Constantinos
Abstract excerpt
Tumor cell adaptation to hypoxic stress is an important determinant of malignant progression. While much emphasis has been placed on the role of HIF-1 in this context, the role of additional mechanisms has not been adequately explored. Here we demonstrate that cells cultured under hypoxic/anoxic conditions and transformed cells in hypoxic areas of tumors activate a translational control program known as the...
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