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Article

Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers

28 Aug 2017

Abstract excerpt

The unfolded protein response (UPR) is an adaptive cellular program used by eukaryotic cells to cope with protein misfolding stress. During tumor development, cancer cells are facing intrinsic (oncogene activation) and extrinsic (limiting nutrient or oxygen supply) challenges, with which they must cope to survive. Moreover, chemotherapy represents an additional extrinsic challenge that cancer cells are facing and...

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PMID: 28846078
DOI: 10.1038/oncsis.2017.72

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