Article

Genome-wide studies define new genetic mechanisms of IgA vasculitis

2024-10-11

Abstract excerpt

IgA vasculitis (IgAV) is a pediatric disease with skin and systemic manifestations. Here, we conducted genome, transcriptome, and proteome-wide association studies in 2,170 IgAV cases and 5,928 controls, generated IgAV-specific maps of gene expression and splicing from blood of 255 pediatric cases, and reconstructed myeloid-specific regulatory networks to define disease master regulators modulated by the newly ide...

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Literature Corpus work: d9c70a45-287f-54e2-b81b-e7bc63cf3655
DOI: 10.1101/2024.10.10.24315041

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