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Article

Residues in the fructose-binding pocket are required for ketohexokinase-A activity.

The Journal of biological chemistry - 1 Aug 2024

Ferreira Juliana C, Villanueva Adrian J, Fadl Samar, Al Adem Kenana, Cinviz Zeynep Nur, Nedyalkova Lyudmila, Cardoso Thyago H S, Andrade Mario Edson, Saksena Nitin K, Sensoy Ozge, Rabeh Wael M

Abstract excerpt

Excessive fructose consumption is a primary contributor to the global surges in obesity, cancer, and metabolic syndrome. Fructolysis is not robustly regulated and is initiated by ketohexokinase (KHK). In this study, we determined the crystal structure of KHK-A, one of two human isozymes of KHK, in the apo-state at 1.85 Å resolution, and we investigated the roles of residues in the fructose-binding pocket by...

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Identifiers

PMID: 38971308
DOI: 10.1016/j.jbc.2024.107538
PMCID: PMC11332825

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