Article

Small-molecule P2RX7 activator sensitizes tumor to immunotherapy and vaccinates mouse against tumor re-challenge

2020-11-20

Abstract excerpt

<h4>ABSTRACT</h4> Only a subpopulation of non-small cell lung cancer (NSCLC) patients responds to immunotherapies, highlighting the urgent need to develop new therapeutic strategies to improve patient outcome. We developed a new chemical positive modulator (HEI3090) of the purinergic P2RX7 receptor that potentiates αPD-1 treatment to effectively control the growth of lung tumors in transplantable and oncogene-ind...

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Literature Corpus work: 93a81e90-4d70-5839-9d03-fb7c5fd71429
DOI: 10.1101/2020.11.19.388900

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