Article

Multiplexed cytokine and antigen mRNA administration generates durable anti-tumor immunity against pancreatic cancer

2025-10-14

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic ductal adenocarcinoma (PDAC) remains a devastating malignancy characterized by limited therapeutic options for advanced disease. Immunotherapy, in particular, has had dismal success rates in the PDAC due to a tumor microenvironment (TME) that contributes to immune exclusion and poor drug delivery. Many cytokines necessary for Natural Killer (NK) and T cell chemotaxis, activation, and...

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Literature Corpus work: b1e7db18-53bf-5ae2-8820-ca7c91bbba50
DOI: 10.1101/2025.10.13.681939

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