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NPRL2 gene therapy induces effective antitumor immunity in KRAS/STK11 mutant anti-PD1 resistant metastatic non-small cell lung cancer (NSCLC) in a humanized mouse model

2024-03-28

Abstract excerpt

NPRL2/TUSC4 is a tumor suppressor gene whose expression is reduced in many cancers including NSCLC. Restoration of NPRL2 expression in cancer cells induces DNA damage which leads to cell cycle arrest and apoptosis. We investigated the antitumor immune responses to NPRL2 gene therapy in aPD1 R / KRAS/STK11 mt NSCLC in a humanized mouse model. Humanized mice were generated by transplanting fresh human cord blood d...

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Literature Corpus work: 2fb1a81e-97bc-559c-b9e0-472a7feca24e
DOI: 10.1101/2024.03.26.586829

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NPRL2 gene therapy induces effective antitumor immunity in KRAS/STK11 mutant anti-PD1 resistant metastatic non-small cell lung cancer (NSCLC) in a humanized mouse modelDOI 10.1101/2024.03.26.586829Read

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