Article

Characterisation of a novel ACE2-based therapeutic with enhanced rather than reduced activity against SARS-CoV2 variants

2021-03-17

Abstract excerpt

<h4>ABSTRACT</h4> The human angiotensin-converting enzyme 2 acts as the host cell receptor for SARS-CoV-2 and the other members of the Coronaviridae family SARS-CoV-1 and HCoV-NL63. Here we report the biophysical properties of the SARS-CoV-2 spike variants D614G, B.1.1.7 and B.1.351 with affinities to the ACE2 receptor and infectivity capacity, revealing weaknesses in the developed neutralising antibody approach...

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Literature Corpus work: 2cea6ba6-d3f8-58c6-977b-de0c264c9f6a
DOI: 10.1101/2021.03.17.435802

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