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Article

Role of N-Glycosylation in SARS-CoV-2 Spike Glycoprotein Conformational Dynamics, Structure, and Function.

ACS infectious diseases - 8 May 2026

Osman Sarah H, Haynes Christopher A, Woolfitt Adrian R, Keppel Theodore R, Barr John R, Wang Dongxia

Abstract excerpt

The SARS-CoV-2 spike protein is heavily glycosylated. These post-translational modifications aid in interactions with human angiotensin-converting enzyme 2 (hACE2), assist in antibody evasion, and help facilitate protein dynamics. However, the exact role glycans play in maintaining the protein structure and conformation is not fully understood. In this study, we elucidated the structural function of these...

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Angiotensin-Converting Enzyme 2
COVID-19
Glycosylation
Polysaccharides
Protein Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Domains

Spike Glycoprotein, Coronavirus

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Identifiers

PMID: 42018455
DOI: 10.1021/acsinfecdis.5c01067
PMCID: PMC13137459

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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