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Computational prediction of the effect of amino acid changes on the binding affinity between SARS-CoV-2 spike protein and the human ACE2 receptor

2021-03-25

Abstract excerpt

<h4>ABSTRACT</h4> The association of the receptor binding domain (RBD) of SARS-CoV-2 viral spike with human angiotensin converting enzyme (hACE2) represents the first required step for viral entry. Amino acid changes in the RBD have been implicated with increased infectivity and potential for immune evasion. Reliably predicting the effect of amino acid changes in the ability of the RBD to interact more strongly w...

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Literature Corpus work
3a970171-cd61-5606-b340-8a7600acd4d9
DOI
10.1101/2021.03.24.436885
Open publication

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