Article

Targeting cancer-associated glycosylation for adoptive T cell therapy of gastro-intestinal and gynecological cancers

2024-09-17

Abstract excerpt

CAR-T cell therapy has provided a significant improvement for patients with chemotherapy-resistant B cell malignancies. However, CAR-T cell treatment of patients with solid cancers has been more difficult, in part because of the heterogeneous expression of tumor-specific cell surface antigens. Here, we describe the generation of a fully human CAR targeting altered glycosylation in secretory epithelial cancers. The...

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Literature Corpus work: fa74dbca-e110-5a63-b0a9-4a90e2c5c35c
DOI: 10.1101/2024.09.12.612750

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