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Spatial and single-cell transcriptomics reveal cellular heterogeneity and a novel cancer-promoting Treg cell subset in human clear-cell renal cell carcinoma

1 Jan 2025

Abstract excerpt

Background Clear cell renal cell carcinoma (ccRCC) is the most common histologic type of RCC. However, the spatial and functional heterogeneity of immunosuppressive cells and the mechanisms by which their interactions promote immunosuppression in the ccRCC have not been thoroughly investigated. Methods To further investigate the cellular and regional heterogeneity of ccRCC, we analyzed single-cell and spatial...

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PMID: 39755578
DOI: 10.1136/jitc-2024-010183

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