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Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrence

2023-01-12

Abstract excerpt

<h4>ABSTRACT</h4> Novel immunotherapy combination therapies have improved outcomes for patients with hepatocellular carcinoma (HCC), but responses are limited to a subset of patients and recurrence can also occur. Little is known about the inter- and intra-tumor heterogeneity in cellular signaling networks within the HCC tumor microenvironment (TME) that underlie responses to modern systemic therapy. We applied s...

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Literature Corpus work
0794cf36-2b0a-5686-a56b-4eefc98c6fbd
DOI
10.1101/2023.01.10.523481
Open publication

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Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrenceDOI 10.1101/2023.01.10.523481
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