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Article

Fundamental roles of the Optineurin gene in the molecular pathology of Amyotrophic Lateral Sclerosis

21 Dec 2023

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive loss of motor neurons (MNs) in the brain and spinal cord. It is caused by multiple factors, including mutations in any one of several specific genes. Optineurin (OPTN) mutation is an essential cause of some familial and sporadic ALS. Besides, as a multifunctional protein, OPTN is highly expressed and conserved in...

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PMID: 38178841
DOI: 10.3389/fnins.2023.1319706

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