Article

The accumulation of orphan ribosomal proteins is a hallmark of ALS

2026-05-19

Abstract excerpt

<h4>Summary</h4> Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of poor prognosis, for which age is the strongest risk factor. Despite significant progress in the discovery of ALS-associated mutations, no model explains how such a diversity of mutations converges in a common pathology. In addition, most ALS cases are sporadic and lack known genetic drivers. We recently reported tha...

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Literature Corpus work: 000cee10-4b52-5eb7-b841-e6262d8f0290
DOI: 10.64898/2026.05.18.725994

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