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Article

The channel-forming Sym1 protein is transported by the TIM23 complex in a presequence-independent manner.

Molecular and cellular biology - 1 Dec 2012

Reinhold Robert, Krüger Vivien, Meinecke Michael, Schulz Christian, Schmidt Bernhard, Grunau Silke D, Guiard Bernard, Wiedemann Nils, van der Laan Martin, Wagner Richard, Rehling Peter, Dudek Jan

Abstract excerpt

The majority of multispanning inner mitochondrial membrane proteins utilize internal targeting signals, which direct them to the carrier translocase (TIM22 complex), for their import. MPV17 and its Saccharomyces cerevisiae orthologue Sym1 are multispanning inner membrane proteins of unknown function with an amino-terminal presequence that suggests they may be targeted to the mitochondria. Mutations affecting...

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Source

Open in PubMed Open full text

Identifiers

PMID: 23045398
DOI: 10.1128/MCB.00843-12
PMCID: PMC3510547

Genes

MPV17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The channel-forming Sym1 protein is transported by the TIM23 complex in a presequence-independent manner.PMID 23045398Read ↗

Role of Tim17 Transmembrane Regions in Regulating the Architecture of Presequence Translocase and Mitochondrial DNA Stability.Semantic proximity Read ↗

A presequence- and voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23.Semantic proximity Read ↗

Hotspots for Disease-Causing Mutations in the Mitochondrial TIM23 Import Complex.Semantic proximity Read ↗

InVivo Dissection of the Intrinsically Disordered Receptor Domain of Tim23.Semantic proximity Read ↗

Biogenesis of Tim23 and Tim17, integral components of the TIM machinery for matrix‐targeted preproteinsSemantic proximity Read ↗

Biogenesis of Tim Proteins of the Mitochondrial Carrier Import Pathway: Differential Targeting Mechanisms and Crossing Over with the Main Import PathwaySemantic proximity Read ↗

Identification of MIM23, a putative component of the protein import machinery of the mitochondrial inner membrane.Semantic proximity Read ↗

Pam17 and Tim44 act sequentially in protein import into the mitochondrial matrix.Semantic proximity Read ↗

Reduced Protein Import via TIM23 SORT Drives Disease Pathology in TIMM50-Associated Mitochondrial Disease.Semantic proximity Read ↗

The role of the TIM8-13 complex in the import of Tim23 into mitochondria.Semantic proximity Read ↗

Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import.Semantic proximity Read ↗

The Tim54p-Tim22p complex mediates insertion of proteins into the mitochondrial inner membrane.Semantic proximity Read ↗

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