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Hotspots for Disease-Causing Mutations in the Mitochondrial TIM23 Import Complex.

Genes - 28 Nov 2024

Jain Sahil, Paz Eyal, Azem Abdussalam

Abstract excerpt

The human mitochondrial proteome comprises approximately 1500 proteins, with only 13 being encoded by mitochondrial DNA. The remainder are encoded by the nuclear genome, translated by cytosolic ribosomes, and subsequently imported into and sorted within mitochondria. The process of mitochondria-destined protein import is mediated by several intricate protein complexes distributed among the four mitochondrial...

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PMID: 39766801
DOI: 10.3390/genes15121534

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Hotspots for Disease-Causing Mutations in the Mitochondrial TIM23 Import Complex.PMID 39766801Read ↗

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Role of Tim17 Transmembrane Regions in Regulating the Architecture of Presequence Translocase and Mitochondrial DNA Stability.Semantic proximity Read ↗

Expression of the human TIMM23 and TIMM23B genes is regulated by the GABP transcription factor.Semantic proximity Read ↗

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Identification of MIM23, a putative component of the protein import machinery of the mitochondrial inner membrane.Semantic proximity Read ↗

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