Article

Biochemical and neurophysiological effects of deficiency of the mitochondrial import protein TIMM50

2024-05-20

Abstract excerpt

TIMM50, an essential TIM23 complex subunit, is suggested to facilitate the import of ∼60% of the mitochondrial proteome. In this study, we characterized a TIMM50 disease causing mutation in human fibroblasts and noted significant decreases in TIM23 core protein levels (TIMM50, TIMM17A/B, and TIMM23). Strikingly, TIMM50 deficiency had no impact on the steady state levels of most of its putative substrates, suggest...

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Literature Corpus work: d41ab409-798d-53f3-bb42-784e3aa67747
DOI: 10.1101/2024.05.20.594480

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