Article
Mitochondrial morphological and functional defects in yeast caused by yme1 are suppressed by mutation of a 26S protease subunit homologue.
Molecular biology of the cell - 1 Aug 1994
Campbell C L, Tanaka N, White K H, Thorsness P E
Abstract excerpt
The absence of functional Yme1p, a putative ATP and zinc-dependent protease localized to mitochondria of yeast, results in abnormal mitochondrial function and morphology. Yeast lacking Yme1p lose DNA from mitochondria at an accelerated rate, fail to grow on nonfermentable carbon sources at 37 degrees C, and have severely deficient growth if mitochondrial DNA suffers large deletions or is completely lost. In place...
Topics
- ATP-Dependent Proteases
- Adenosine Triphosphatases
- Amino Acid Sequence
- Cloning, Molecular
- DNA, Fungal
- DNA, Mitochondrial
- Genes, Fungal
- Genes, Suppressor
- Microscopy, Electron
- Mitochondria