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Article

PEG10 is associated with treatment-induced neuroendocrine prostate cancer

23 Apr 2019

Abstract excerpt

Neuroendocrine (NE) differentiation of advanced prostate adenocarcinoma following androgen receptor (AR) axis-directed therapy is becoming increasingly recognized. Several models of this transdifferentiation provide insight into its molecular pathogenesis and have highlighted the placental gene PEG10 for further study. Using our unique model of enzalutamide resistance (ENZR) and NE differentiation, we studied...

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PMID: 31013476
DOI: 10.1530/jme-18-0226

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