Article

Structural basis for inhibition of human primase by arabinofuranosyl nucleoside analogues Fludarabine and Vidarabine

2019-04-11

Abstract excerpt

<h4>SUMMARY</h4> Nucleoside analogues are widely used in clinical practice as chemotherapy drugs. Arabinose nucleoside derivatives such as Fludarabine are effective in the treatment of patients with acute and chronic leukemias and non-Hodgkin lymphomas. Although nucleoside analogues are generally known to function by inhibiting DNA synthesis in rapidly proliferating cells, the identity of their in vivo targets a...

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Literature Corpus work: a0e2f69d-1667-5c91-a76a-9a91969303c5
DOI: 10.1101/605279

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