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<i>Giardia intestinalis</i> deoxyadenosine kinase has a unique tetrameric structure that enables high substrate affinity and makes the parasite sensitive to deoxyadenosine analogues

2023-12-18

Abstract excerpt

Giardia intestinalis is a protozoan parasite causing giardiasis, a severe, sometimes even life-threatening, diarrheal disease. Giardia is one of only a few known organisms that lack de novo synthesis of DNA building blocks, and the parasite is therefore completely dependent on salvaging deoxyribonucleosides from the host. The deoxyribonucleoside kinases (dNKs) needed for this salvage are generally divided into t...

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Identifiers and source

Literature Corpus work
2fc625e2-3e4c-5f27-88dd-0f0a406319b2
DOI
10.1101/2023.12.18.572228
Open publication

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<i>Giardia intestinalis</i> deoxyadenosine kinase has a unique tetrameric structure that enables high substrate affinity and makes the parasite sensitive to deoxyadenosine analoguesDOI 10.1101/2023.12.18.572228
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