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Chemistry of Fluorinated Pyrimidines in the Era of Personalized Medicine

29 Jul 2020

Abstract excerpt

We review developments in fluorine chemistry contributing to the more precise use of fluorinated pyrimidines (FPs) to treat cancer. 5-Fluorouracil (5-FU) is the most widely used FP and is used to treat > 2 million cancer patients each year. We review methods for 5-FU synthesis, including the incorporation of radioactive and stable isotopes to study 5-FU metabolism and biodistribution. We also review methods for...

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PMID: 32751071
DOI: 10.3390/molecules25153438

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