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Article

Wild type and mutant amyloid precursor proteins influence downstream effects of proteasome and autophagy inhibition.

Biochimica et biophysica acta - 1 Feb 2014

Cecarini Valentina, Bonfili Laura, Cuccioloni Massimiliano, Mozzicafreddo Matteo, Rossi Giacomo, Keller Jeffrey N, Angeletti Mauro, Eleuteri Anna Maria

Abstract excerpt

Cells rely on complementary proteolytic pathways including the ubiquitin-proteasome system and autophagy to maintain proper protein degradation. There is known to be considerable interplay between them, whereby the loss of one clearance system results in compensatory changes in other proteolytic pathways of the cell. Disturbances in proteolysis are known to occur in Alzheimer's disease, and potentially contribute...

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Source

Identifiers

PMID: 24215712
DOI: 10.1016/j.bbadis.2013.11.002

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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