Article

LincRNAs enable germ cells differentiation by promoting PUF proteins condensation

2023-08-27

Abstract excerpt

Successful tissue homeostasis depends on a balance between proliferation and differentiation. Two PUF proteins, FBF-1 and FBF-2, maintain stem-cells proliferation in C. elegans germ-cells by binding and destabilizing transcripts which promote meiotic entry. However, it is unclear how meiosis initiates because the FBF are also present at significant levels in late proliferative and early meiotic cells. We found th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a0bac89f-cfbb-5c46-bcca-0f7fef19a58c
DOI: 10.1101/2023.08.27.554978

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LincRNAs enable germ cells differentiation by promoting PUF proteins condensationDOI 10.1101/2023.08.27.554978Read

C. elegans RNA-binding proteins PUF-8 and MEX-3 function redundantly to promote germline stem cell mitosisSemantic proximity Read

The Puf RNA-binding proteins FBF-1 and FBF-2 inhibit the expression of synaptonemal complex proteins in germline stem cells.Semantic proximity Read

A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans.Semantic proximity Read

Towards identifying subnetworks from FBF binding landscapes in <i>Caenorhabditis</i> spermatogenic or oogenic germlinesSemantic proximity Read

COP9 signalosome component CSN-5 stabilizes PUF proteins FBF-1 and FBF-2 in <i>Caenorhabditis elegans</i> germline stem cellsSemantic proximity Read

Redundant control of the Caenorhabditis elegans sperm/oocyte switch by PUF-8 and FBF-1, two distinct PUF RNA-binding proteins.Semantic proximity Read

Regulation of the mitosis/meiosis decision in the <i>Caenorhabditis elegans</i> germlineSemantic proximity Read

Splicing Machinery Facilitates Post-Transcriptional Regulation by FBFs and Other RNA-Binding Proteins in Caenorhabditis elegans Germline.Semantic proximity Read

TurboID-based proximity labeling identifies novel germline proteins that maintain E granule integrity and small RNA homeostasis in <i>C. elegans</i>Semantic proximity Read

The zinc-finger transcription factor LSL-1 is a major regulator of the germline transcriptional program in <i>C. elegans</i>Semantic proximity Read

The PUF RNA-binding protein, FBF-2, maintains stem cells without binding to RNA.Semantic proximity Read

HERD-1 mediates multiphase condensate immiscibility to regulate small RNA-driven transgenerational epigenetic inheritance.Semantic proximity Read