Article
Genome-wide detection of DNase I hypersensitive sites in single cells and FFPE tissue samples.
Nature - 3 Dec 2015
Jin Wenfei, Tang Qingsong, Wan Mimi, Cui Kairong, Zhang Yi, Ren Gang, Ni Bing, Sklar Jeffrey, Przytycka Teresa M, Childs Richard, Levens David, Zhao Keji
Abstract excerpt
DNase I hypersensitive sites (DHSs) provide important information on the presence of transcriptional regulatory elements and the state of chromatin in mammalian cells. Conventional DNase sequencing (DNase-seq) for genome-wide DHSs profiling is limited by the requirement of millions of cells. Here we report an ultrasensitive strategy, called single-cell DNase sequencing (scDNase-seq) for detection of genome-wide...
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