Article

Calpain-dependent antigen processing generates a tumor-associated epitope recognized by osteosarcoma-infiltrating T cells

2026-04-29

Abstract excerpt

<title>Abstract</title> <p>Osteosarcoma is an aggressive malignant bone tumor with limited treatment options, particularly in metastatic or treatment-resistant disease. Although T cell-based immunotherapies have shown promise in other solid tumors, their application to osteosarcoma has been hindered by the limited characterization of antigens recognized by tumor-infiltrating lymphocytes (TILs). In this study, we...

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Literature Corpus work: a0a46431-fa20-5a66-91b2-bfc2af954845
DOI: 10.21203/rs.3.rs-9104987/v1

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