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Article

Immuno-genomic landscape of osteosarcoma.

Nature communications - 21 Feb 2020

Wu Chia-Chin, Beird Hannah C, Andrew Livingston J, Advani Shailesh, Mitra Akash, Cao Shaolong, Reuben Alexandre, Ingram Davis, Wang Wei-Lien, Ju Zhenlin, Hong Leung Cheuk, Lin Heather, Zheng Youyun, Roszik Jason, Wang Wenyi, Patel Shreyaskumar, Benjamin Robert S, Somaiah Neeta, Conley Anthony P, Mills Gordon B, Hwu Patrick, Gorlick Richard, Lazar Alexander, Daw Najat C, Lewis Valerae, Futreal P Andrew

Abstract excerpt

Limited clinical activity has been seen in osteosarcoma (OS) patients treated with immune checkpoint inhibitors (ICI). To gain insights into the immunogenic potential of these tumors, we conducted whole genome, RNA, and T-cell receptor sequencing, immunohistochemistry and reverse phase protein array profiling (RPPA) on OS specimens from 48 pediatric and adult patients with primary, relapsed, and metastatic OS....

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Source

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Identifiers

PMID: 32081846
DOI: 10.1038/s41467-020-14646-w
PMCID: PMC7035358

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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