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Genomics and the Immune Landscape of Osteosarcoma.

Advances in experimental medicine and biology - 1 Jan 2020

Wu Chia-Chin, Livingston J Andrew

Abstract excerpt

Conventional osteosarcoma (OS) is a high-grade intraosseous malignancy with production of osteoid matrix; however, a deeper dive into the underlying genetics reveals genomic complexity and instability that result in significant tumor heterogeneity. While early karyotyping studies demonstrated aneuploidy with chromosomal complexity and structural rearrangements, further investigations have identified few recurrent...

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Bone Neoplasms
DNA Copy Number Variations
Genome, Human
Genomics
High-Throughput Nucleotide Sequencing

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PMID: 32767232
DOI: 10.1007/978-3-030-43085-6_2

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