Article

Increased CD33 levels tune activation and function of induced human microglial cells through inhibition of the TREM2 pathway

2026-01-30

Abstract excerpt

<h4>Summary</h4> The microglial CD33 gene is overexpressed in the brains of individuals with Alzheimer’s disease, and multiple CD33 genetic variants are directly linked to disease risk. Here, we investigate CD33 function in induced human microglial cells by increasing or decreasing CD33 levels with AAV6-mediated gene transfer and with CD33-targeting siRNA, respectively. Phagocytosis of oligomeric amyloid beta i...

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Literature Corpus work: 03b18003-d5cb-57ac-8175-07607c5278aa
DOI: 10.64898/2026.01.28.701050

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