Back to search

Article

Heterologous expression of human pro-inflammatory Caspase-1 in <i>Saccharomyces cerevisiae</i> and comparison to pro-apoptotic Caspase-8

2021-02-08

Abstract excerpt

Caspases are a family of cysteine proteases that play an essential role in inflammation, apoptosis, cell death, and development. Here we delve into the effects caused by heterologous expression of human Caspase-1 in the yeast Saccharomyces cerevisiae and compare them to those of Caspase-8. Overexpression of both caspases in the heterologous model led to their activation, and caused mitochondrial depolarization, R...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a098c0d8-eee5-5609-a808-ddcc14a66e1f
DOI
10.1101/2021.02.07.430150
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Heterologous expression of human pro-inflammatory Caspase-1 in <i>Saccharomyces cerevisiae</i> and comparison to pro-apoptotic Caspase-8DOI 10.1101/2021.02.07.430150
Modeling Necroptotic and Pyroptotic Signaling in <i>Saccharomyces cerevisiae</i>Semantic proximity
Human initiator caspases trigger apoptotic and autophagic phenotypes in Saccharomyces cerevisiae.Semantic proximity
Human IRAK kinases differentially alter metabolic regulation and mitochondrial function in <i>Saccharomyces cerevisiae</i>Semantic proximity
Apoptosis in yeast: a new model system with applications in cell biology and medicine.Semantic proximity
A non-death role of the yeast metacaspase: Yca1p alters cell cycle dynamics.Semantic proximity
The S. cerevisiae HtrA-like protein Nma111p is a nuclear serine protease that mediates yeast apoptosis.Semantic proximity
Viruses activate a genetically conserved cell death pathway in a unicellular organismSemantic proximity
Metacaspase Yca1 is required for clearance of insoluble protein aggregates.Semantic proximity
New insights into cancer‐related proteins provided by the yeast modelSemantic proximity
Expressing and functional analysis of mammalian apoptotic regulators in yeastSemantic proximity
Gene-dependent cell death in yeast.Semantic proximity
From the Bakery to the Brain Business: Developing Inducible Yeast Models of Human Neurodegenerative DisordersSemantic proximity
Select a neighboring publication to make it the new centre.