Article
Metacaspase Yca1 is required for clearance of insoluble protein aggregates.
Proceedings of the National Academy of Sciences of the United States of America - 27 Jul 2010
Lee Robin E C, Brunette Steve, Puente Lawrence G, Megeney Lynn A
Abstract excerpt
In complex organisms, caspase proteases mediate a variety of cell behaviors, including proliferation, differentiation, and programmed cell death/apoptosis. Structural homologs to the caspase family (termed metacaspases) engage apoptosis in single-cell eukaryotes, yet the molecular mechanisms that contribute to nondeath roles are currently undefined. Here, we report an unexpected role for the Saccharomyces...
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