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Viruses activate a genetically conserved cell death pathway in a unicellular organism

1 Aug 2005

Abstract excerpt

Given the importance of apoptosis in the pathogenesis of virus infections in mammals, we investigated the possibility that unicellular organisms also respond to viral pathogens by activating programmed cell death. The M1 and M2 killer viruses of Saccharomyces cerevisiae encode pore-forming toxins that were assumed to kill uninfected yeast cells by a nonprogrammed assault. However, we found that yeast persistently...

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PMID: 16061692
DOI: 10.1083/jcb.200503069

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