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Article

Human initiator caspases trigger apoptotic and autophagic phenotypes in Saccharomyces cerevisiae.

Biochimica et biophysica acta - 1 Mar 2009

Lisa-Santamaría Patricia, Neiman Aaron M, Cuesta-Marbán Alvaro, Mollinedo Faustino, Revuelta José L, Jiménez Alberto

Abstract excerpt

Caspases are a family of proteases that participate in the progression and execution of the apoptotic program. However, regulation of the caspase activation and their substrates has not yet been fully elucidated. Here we explore the effect of the ectopic expression of the human initiator caspases-8 and -10 in Saccharomyces cerevisiae. Our results showed that the expression of human CASP10 and CASP8 triggers...

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Source

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Identifiers

PMID: 19166881
DOI: 10.1016/j.bbamcr.2008.12.016
PMCID: PMC2647587

Genes

CASP10
CASP8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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