Article

Enhancer adoption by an LTR retrotransposon generates viral-like particles causing developmental limb phenotypes

2024-09-15

Abstract excerpt

Mammalian genomes are scattered with transposable elements (TEs). TEs are epigenetically silenced to prevent harmful effects caused by either global activation leading to genome instability or insertional mutation disturbing gene transcription. However, whether the activation of a single element can contribute to pathological phenotypes without directly affecting gene expression is largely unknown. Here, we show t...

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Identifiers and source

Literature Corpus work: a09566b1-c297-5560-9ee8-be326c38d916
DOI: 10.1101/2024.09.13.612906

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