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Article

NF-κB and STAT3 in glioblastoma: therapeutic targets coming of age

29 Sept 2014

Abstract excerpt

Since we last addressed the roles of NF-κB and JAK/STAT3 signaling in glioblastoma (GBM) 5 years ago, tremendous strides have been made in the understanding of these two pathways in glioma biology. Contributing to prosurvival mechanisms, cancer stem cell maintenance and treatment resistance, both NF-κB and STAT3 have been characterized as major drivers of GBM. In this review, we address general improvements in...

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PMID: 25262780
DOI: 10.1586/14737175.2014.964211

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