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Article

Regulatory Mechanisms of STAT3 in GBM and its Impact on TMZ Resistance

2 Jun 2025

Abstract excerpt

STAT3, a key member of the Signal Transducer and Activator of Transcription (STAT) family, plays a vital role in the development and progression of glioblastoma (GBM), as well as in the resistance to the chemotherapy drug temozolomide (TMZ). This review outlines the dysregulation of STAT3 in GBM, focusing on its activation mechanisms and its contribution to TMZ resistance. STAT3 can be activated by cytokines,...

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PMID: 40353463
DOI: 10.2174/0118761429386400250415053351

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