Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments

Abstract excerpt

The release of inorganic phosphate (P i ) from actin filaments constitutes a key step in their regulated turnover, which is fundamental to many cellular functions. However, the molecular mechanisms underlying P i release from both the core and barbed end of actin filaments remain unclear. Here, we combine cryo-EM with molecular dynamics simulations and in vitro reconstitution to demonstrate how actin releases P...

Topics

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• Actins
• Adenosine Triphosphate
• Models, Molecular
• Mutation
• Phosphates
• Protein Conformation
• Recombinant Proteins
• Valine

Identifiers and source

Literature Corpus work

a06f4697-c7cb-5179-af06-c2507cb65b26

DOI

10.1101/2023.03.25.534205