Article

From GWAS to Mechanism: Synaptic Pruning Emerges as a Key Polygenic Driver of Cognitive Ability

2026-01-06

Abstract excerpt

Human intelligence is strongly heritable, but the genes that fine-tune the brain's wiring are still being mapped. We re-examined the large IQ genome-wide association study by Savage et al. (2018; N = 269 867) with three complementary tools—partitioned SNP-heritability, MAGMA gene tests, and a transcriptome-wide association study (TWAS)—to ask whether synaptic pruning makes an independent contribution beyond classi...

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Literature Corpus work: a06ef37c-c5b5-5c4d-b5ad-be4c04db33ae
DOI: 10.20944/preprints202601.0385.v1

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