Article
Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals.
Molecular psychiatry - 1 Feb 2019
Coleman Jonathan R I, Bryois Julien, Gaspar Héléna A, Jansen Philip R, Savage Jeanne E, Skene Nathan, Plomin Robert, Muñoz-Manchado Ana B, Linnarsson Sten, Crawford Greg, Hjerling-Leffler Jens, Sullivan Patrick F, Posthuma Danielle, Breen Gerome
Abstract excerpt
Variance in IQ is associated with a wide range of health outcomes, and 1% of the population are affected by intellectual disability. Despite a century of research, the fundamental neural underpinnings of intelligence remain unclear. We integrate results from genome-wide association studies (GWAS) of intelligence with brain tissue and single cell gene expression data to identify tissues and cell types associated...
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